Glycogen utilization and ischemic injury in the isolated rat heart
نویسندگان
چکیده
منابع مشابه
Glycogen utilization and ischemic injury in the isolated rat heart.
INTRODUCTION Fasting increases myocardial glycogen content and has been shown to limit injury and improve recovery following no-flow ischaemia in the isolated heart. However, the protective role of glycogen loading per se in fed animals has been questioned by data in preconditioned animals showing that reduced glycogenolysis may be protective prior to no-flow ischemia. Therefore, we hypothesize...
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Differences in energy metabolism during beta(1)- and beta(2)-adrenergic receptor (AR) stimulation have been shown to translate to differences in the elicited functional responses. It has been suggested that differential access to glycogen during beta(1)- compared with beta(2)-AR stimulation may influence the peak functional response and modulation of the response during sustained adrenergic sti...
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BACKGROUND/AIMS Myocardium ischemia-reperfusion (I/R) injury can be caused by imbalances in cellular metabolism. Lactate, transported by monocarboxylate transporters (MCTs), has been implicated as a mechanism in this process. The present study was designed to investigate the expression and functional role of MCTs in rat hearts during ischemia and reperfusion. METHODS Langendorff-perfused rat ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1997
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(97)00087-4